PNC 27 10 mg

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Research Use Only

All products are intended solely for laboratory research and are not for human or animal consumption. By purchasing, the buyer agrees to use these products in compliance with all applicable laws.

PNC 27

PNC-27 is a chimeric peptide consisting of a segment derived from the p53 tumor suppressor protein (residues 12–26) fused to a membrane‑penetrating leader sequence^[1]. Preclinical studies indicate that PNC-27 selectively binds to HDM‑2 expressed on the surface of cancer cells, inducing membrane destabilization and necrotic cell death while sparing normal cells^[2]^[6]. Research in mouse tumor models has demonstrated inhibition of cancer cell growth via intraperitoneal administration^[4]. No human clinical studies have been conducted, and all dosing protocols remain theoretical extrapolations from preclinical work.